Publications

51. Feng Y, Zhang Z, Tang W, Dai Y*. Gel/hydrogel‐based in situ biomaterial platforms for cancer postoperative treatment and recovery. Exploration. 2023. doi:10.1002/exp.20220173.

50. Han Z*, Driedonks T, Tang W, Zhou Z, McNally L. Editorial: Molecular imaging for tracking drug delivery. Frontiers in Pharmacology, 2023; 14. doi:10.3389/fphar.2023.1195229

49. Pan Y, Tang W, Fan W*, Zhang J*, Chen X*. Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection. Chem Soc Rev. 2022; 51(23): 9759-9830.

48. Tang W*, Zhang Y, Zhu G*. Pulmonary Delivery of Mucosal Nanovaccines. Nanoscale. 2022; 14(2): 263-276.

47. Huang L, Feng J, Fan W*, Tang W, Rong X, Liao W, Wei Z, Xu Y, Wu A*, Chen X*, Shen Z*. Intelligent Pore Switch of Hollow Mesoporous Organosilica Nanoparticles for High Contrast Magnetic Resonance Imaging and Tumor-Specific Chemotherapy. Nano Lett. 2021; 21(22): 9551-9559.

46. Tang W, Yang Z*, He L, Deng L, Fathi P, Zhu S, Li L, Shen B, Wang Z, Jacobson O, Song J, Zou J, Hu P, Wang M, Mu J, Cheng Y, Ma Y, Tang L, Fan W*, Chen X*. A Hybrid Semiconducting Organosilica-Based O₂ Nanoeconomizer for On-Demand Synergistic Photothermally-Boosted Radiotherapy. Nat Comm. 2021; 12, 523.

45. Zhou S, Zhen Z, Paschall AV, Xue L, Yang X, Bebin-Blackwell AG, Cao Z, Zhang W, Wang M, Teng Y, Zhou G, Li Z, Avci FY, Tang W*, Xie J*. FAP-Targeted Photodynamic Therapy Mediated by Ferritin Nanoparticles Elicits an Immune Response against Cancer Cells and Cancer Associated Fibroblasts. Adv Funct Mater. 2021; 31(7): 2007017.

44. Cheng Y, Jiao X, Wang Z, Jacobson O, Aronova MA, Ma Y, He L, Liu Y, Tang W, Deng L, Zou J, Yang Z, Zhang M, Wen Y*, Fan W*, Chen X*. Biphasic Synthesis of Biodegradable Urchin-Like Mesoporous Organosilica Nanoparticles for Enhanced Cellular Internalization and Precision Cascaded Therapy. Biomater Sci. 2021; 9(7): 2584-2597.

43. He L, Ni Q, Mu J, Fan W*, Liu L, Wang Z, Li L, Tang W, Liu Y, Cheng Y, Tang L, Yang Z, Liu Y, Zou J, Yang W, Jacobson O, Zhang F, Huang P*, Chen X*. Solvent-Assisted Self-Assembly of a Metal-Organic Framework Based Biocatalyst for Cascade Reaction Driven Photodynamic Therapy. J Am Chem Soc. 2020; 142(14): 6822-6832.

42. Zou J, Zhu J, Yang Z*, Li L, Fan W, He L, Tang W, Deng L, Mu J, Ma Y, Cheng Y, Huang W, Dong X*, Chen X*. A Phototheranostic Strategy to Continuously Deliver Singlet Oxygen in the Dark and Hypoxic Tumor Microenvironment. Angew Chem Int Ed Engl. 2020; 59(23): 8833-8838.

41. Mu J, He L*, Fan W, Tang W, Wang Z, Jiang C, Zhang D, Liu Y, Deng H, Zou J, Jacobson O, Qu J, Huang P*, Chen X*. Cascade Reactions Catalyzed by Planar Metal-Organic Framework Hybrid Architecture for Combined Cancer Therapy. Small. 2020; 16: 2004016.

40. Shen Z, Liu T, Yang Z, Zhou Z, Tang W, Fan W*, Liu Y, Mu J, Li L, Bregadze VI, Mandal SK, Druzina AA, Wei Z, Qiu X*, Wu A*, Chen X*. Small-Sized Gadolinium Oxide-Based Nanoparticles for High-Efficiency Theranostics of Orthotopic Glioblastoma. Biomaterials. 2020; 235: 119783.

39. Tang W, Fan W*, Lau J, Deng L, Shen Z, Chen X*. Emerging Blood-Brain-Barrier-Crossing Nanotechnology for Brain Cancer Theranostics. Chem Soc Rev. 2019; 48: 2967-3014.

38. Tang W, Fan W*, Zhang W, Yang Z, Li L, Wang Z, Chiang Y, Liu Y, Deng L, He L, Shen Z, Jacobson O, Aronova MA, Jin A, Xie J*, Chen X*. Wet/Sono-Chemical Synthesis of Enzymatic Two-Dimensional MnO₂ Nanosheets for Synergistic Catalysis-Enhanced Phototheranostics. Adv Mater. 2019; 201900401.

37. Yang Z^#, Song J^#, Tang W^#, Fan W, Dai Y, Shen Z, Lin L, Cheng S, Liu Y, Niu G, Rong P, Wang W*, Chen X*. Stimuli-Responsive Nanotheranostics for Real-Time Monitoring Drug Release by Photoacoustic Imaging. Theranostics. 2019; 9(2): 526-536. (Inside Back Cover).

36. Fan W, Tang W*, Lau J, Shen Z, Xie J, Shi J, Chen X*. Breaking the Depth Dependence by Nanotechnology-Enhanced X-Ray-Excited Deep Cancer Theranostics. Adv Mater. 2019; 201806381.

35. Lin LS^#, Wang JF^#, Song J^#, Liu Y, Zhu G, Dai Y, Shen Z, Tian R, Song J, Wang Z, Tang W, Yu G, Zhou Z, Yang Z, Huang T, Niu G, Yang HH, Chen ZY*, Chen X*. Cooperation of Endogenous and Exogenous Reactive Oxygen Species Induced by Zinc Peroxide Nanoparticles to Enhance Oxidative Stress-Based Cancer Therapy. Theranostics. 2019; 9(24): 7200-7209.

34. Yang Z^#, Fan W^#, Zou J, Tang W, Li L, He L, Shen Z, Wang Z, Jacobson O, Aronova MA, Rong P*, Song J, Wang W*, Chen X*. Precision Cancer Theranostic Platform by In Situ Polymerization in Perylene Diimide-Hybridized Hollow Mesoporous Organosilica Nanoparticles. J Am Chem Soc. 2019; 141(37): 14687-14698.

33. Li L^#, Yang Z^#, Fan W, He L, Cui C, Zou J, Tang W, Jacobson O, Wang Z, Niu G, Hu S*, Chen X*. In Situ Polymerized Hollow Mesoporous Organosilica Biocatalysis Nanoreactor for Enhancing ROS-Mediated Anticancer Therapy. Adv Funct Mater. 2019; 201907716.

32. Shen Z, Fan W*, Yang Z, Liu Y, Bregadze VI, Mandal SK, Yung BC, Lin L, Liu T*, Tang W, Shan L, Liu Y, Zhu S, Wang S, Yang W, Bryant LH, Nguyen DT, Wu A*, Chen X*. Exceedingly Small Gadolinium Oxide Nanoparticles with Remarkable Relaxivities for Magnetic Resonance Imaging of Tumors. Small. 2019; 15(41): 1903422.

31. Tang L, Yu F, Tang B, Yang Z, Fan W*, Zhang M, Wang Z, Jacobson O, Zhou Z, Li L, Liu Y, Kiesewetter D, Tang W, He L, Ma Y, Niu G, Zhang X*, Chen X*. Tumor Microenvironment-Activated Ultrasensitive Nanoprobes for Specific Detection of Intratumoral Glutathione by Ratiometric Photoacoustic Imaging. ACS Appl Mater Interfaces. 2019; 11(31): 27558-27567.

30. Fan W^#, Lu N^#, Shen Z*, Tang W, Shen B, Cui Z, Shan L, Yang Z, Wang Z, Jacobson O, Zhou Z, Liu Y, Hu P, Yang W, Song J, Zhang Y, Zhang L, Khashab NM, Aronova MA, Lu G*, Chen X*. Generic Synthesis of Small-Sized Hollow Mesoporous Organosilica Nanoparticles for Oxygen-Independent X-Ray-Activated Synergistic Therapy. Nat Comm. 2019; 10: 1241.

29. Li L^#, Yang Z^#, Zhu S, He L, Fan W, Tang W, Zou J, Shen Z, Zhang M, Tang L, Dai Y, Niu G, Hu S*, Chen X*. A Rationally Designed Semiconducting Polymer Brush for NIR-II Imaging-Guided Light-Triggered Remote Control of CRISPR/Cas9 Genome Editing. Adv Mater. 2019; 31: 1901187.

28. Shan L, Fan W*, Wang W, Tang W, Yang Z, Wang Z, Liu Y, Shen Z, Dai Y, Cheng S, Jacobson O, Zhai K, Hu J, Ma Y, Kiesewetter D, Gao G, Chen X*. Organosilica-Based Hollow Mesoporous Bilirubin Nanoparticles for Antioxidation-Activated Self-Protection and Tumor-Specific Deoxygenation-Driven Synergistic Therapy. ACS Nano. 2019; 13(8): 8903-8916.

27. Shan L, Gao G, Wang W, Tang W, Wang Z, Yang Z, Fan W, Zhu G, Zhai K, Jacobson O, Dai Y*, Chen X*. Self-Assembled Green Tea Polyphenol-Based Coordination Nanomaterials to Improve Chemotherapy Efficacy by Inhibition of Carbonyl Reductase 1. Biomaterials. 2019; 210: 62-69.

26. Liu Y, Gong CS, Dai Y, Yang Z, Yu G, Liu Y, Zhang M, Lin L, Tang W, Zhou Z, Zhu G, Chen J, Jacobson O, Kiesewetter D, Wang Z*, Chen X*. In Situ Polymerization on Nanoscale Metal-Organic Frameworks for Enhanced Physiological Stability and Stimulus-Responsive Intracellular Drug Delivery. Biomaterials. 2019; 218: 119365.

25. Yang Z, Dai Y*, Shan L, Shen Z, Wang Z, Yung BC, Jacobson O, Liu Y, Tang W, Wang S, Lin L, Niu G, Huang P*, Chen X*. Tumor Microenvironment-Responsive Semiconducting Polymer-Based Self-Assembling Nanotheranostics. Nanoscale Horiz. 2019; 4: 426-433.

24. Zhou Z, Bai R*, Wang Z, Bryant H, Lang L, Merkle H, Munasinghe J, Tang L, Tang W, Tian R, Yu G, Ma Y, Niu G, Gao J*, Chen X*. An Albumin-Binding T1- T2 Dual-Modal MRI Contrast Agents for Improved Sensitivity and Accuracy in Tumor Imaging. Bioconjug Chem. 2019; 30: 1821-1829.

23. Tang W, Fan W*, Wang Z, Zhang W, Zhou S, Liu Y, Yang Z, Shao E, Zhang G, Jacobson O, Shan L, Tian R, Cheng S, Lin L, Dai Y, Zhen Y, Niu G, Xie J*, Chen X*. Acidity/Reducibility Dual-Responsive Hollow Mesoporous Organosilica Nanoplatforms for Tumor-Specific Self-Assembly and Synergistic Therapy. ACS Nano. 2018; 12(12): 12269-12283.

22. Tang W, Yang Z*, Wang S, Wang Z, Song J, Yu G, Fan W, Dai Y, Wang J, Shan L, Niu G, Fan Q*, Chen X*. Organic Semiconducting Photoacoustic Nanodroplets for Laser-Activatable Ultrasound Imaging and Combinational Cancer Therapy. ACS Nano. 2018; 12(3): 2610-2622.

21. Yang Z^#, Fan W^#, Tang W^#, Shen Z, Dai Y, Song J, Wang Z, Liu Y, Lin L, Shan L, Liu Y, Jacobson O, Rong P, Wang W*, Chen X*. Near-Infrared Semiconducting Polymer Brush and pH/GSH-Responsive Polyoxometalate Cluster Hybrid Platform for Enhanced Tumor-Specific Phototheranostics. Angew Chem. 2018; 130(43): 14297-14301.

20. Zhang W^#, Wang M^#, Tang W, Wen R, Zhou S, Lee C, Wang H, Jiang W, Delahunty I, Zhen Z, Chen H, Chapman M, Wu Z, Howerth E, Cai H, Li Z*, Xie J*. Nanoparticle-Laden Macrophages for Tumor-Tropic Drug Delivery. Adv Mater. 2018; 30: 1805557.

19. Yang Z, Dai Y, Yin C, Fan Q*, Zhang W, Song J, Yu G, Tang W, Fan W, Yung BC, Li J, Li X, Li X, Tang Y, Huang W, Song J*, Chen X*. Activatable Semiconducting Theranostics: Simultaneous Generation and Ratiometric Photoacoustic Imaging of Reactive Oxygen Species In Vivo. Adv Mater. 2018; 30: 1707509.

18. Lin LS^#, Song J^#, Song L, Ke K, Liu Y, Zhou Z, Shen Z, Li J, Yang Z, Tang W, Niu G, Yang H*, Chen X*. Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO₂ -Based Nanoagent to Enhance Chemodynamic Therapy. Angew Chem Int Ed Engl. 2018; 57(18): 4902-4906.

17. Zhao W, Cheng R, Lim SH, Miller JR, Zhang W, Tang W, Xie J, Mao L*. Biocompatible and Label-Free Separation of Cancer Cells from Cell Culture Lines from White Blood Cells in Ferrofluids. Lab Chip. 2017; 17(23): 2243-2255.

16. Zhen Z^#, Tang W^#, Wang M, Zhou S, Wang H, Wu Z, Hao Z, Li Z, Liu L*, Xie J*. Protein Nanocage Mediated Fibroblast-Activation Protein Targeted Photoimmunotherapy To Enhance Cytotoxic T Cell Infiltration and Tumor Control. Nano Lett. 2017; 17(2): 862-869.

15. Yoon Y, Tang W, Chen X*. Ultrasound-Mediated Diagnosis and Therapy Based on Ultrasound Contrast Agents. Small Methods. 2017; 1(8): 1700173.

14. Tang W, Zhen Z, Wang M, Wang H, Chuang YJ, Zhang W, Wang G, Todd T, Cowger T, Chen H, Liu L, Li Z*, Xie J*. Red Blood Cell-Facilitated Photodynamic Therapy for Cancer Treatment. Adv Funct Mater. 2016; 26: 1757-1768.

13. Wang G, Chen H*, Tang W, Lee D, Xie, J*. Gd and Eu Co-doped Nanoscale Metal-Organic Framework as A T₁-T₂ Dual-modal Contrast Agent for Magnetic Resonance Imaging. Tomography. 2016; 2(3): 179-187.

12. Cowger T, Tang W, Zhen Z, Hu K, Rink D, Todd T, Wang G, Zhang W, Chen H, Xie J*. Casein-Coated Fe₅C₂ Nanoparticles with Superior r₂ Relaxivity for Liver-Specific Magnetic Resonance Imaging. Theranostics. 2015; 5(11): 1125-1132.

11. Zhen Z, Tang W, Zhang W, Xie J*, Folic Acid Conjugated Ferritins as Photosensitizer Carriers for Photodynamic Therapy. Nanoscale. 2015; 7(23): 10330-10333.

10. Zhen Z,^# Tang W^#, Chuang YJ, Todd T, Zhang W, Lin X, Niu G, Liu G, Wang L, Pan Z, Chen X, Xie J*. Tumor Vasculature Targeted Photodynamic Therapy for Enhanced Delivery of Nanoparticles. ACS Nano. 2014; 8(6): 6004-6013.

9. Tang W, Zhen Z, Yang C, Wang L, Cowger T, Chen H, Todd T, Hekmatyar K, Zhao Q, Hou Y*, Xie J*. Fe₅C₂ Nanoparticles with High MRI Contrast Enhancement for Tumor Imaging. Small. 2014; 10(7): 1245-1249.

8. Chen H^#, Wang GD^#, Tang W, Todd T, Zhen Z, Tsang C, Hekmatyar K, Cowger T, Hubbard R B, Zhang W, Stickney J, Shen B*, Xie J*. Gd-Encapsulated Carbonaceous Dots with Efficient Renal Clearance for Magnetic Resonance Imaging. Adv Mater. 2014; 26: 6761-6766.

7. Zhen Z, Tang W, Todd T, Xie J*. Ferritins as Nanoplatforms for Imaging and Drug Delivery. Expert Opin on Drug Deliv. 2014; 11(12): 1913-1922.

6. Todd T, Zhen Z, Tang W, Chen H, Wang G, Chuang YJ, Deaton K, Pan Z, Xie J*. Iron Oxide Nanoparticle Encapsulated Diatoms for Magnetic Delivery of Small Molecules to Tumors. Nanoscale. 2014; 6(4): 2073-2076.

5. Wang L, Tang W, Zhen Z, Chen H, Xie J, Zhao Q*. Improving Detection Specificity of Iron Oxide Nanoparticles (IONPs) Using the SWIFT Sequence with Long T(2) Suppression. Magn Reson Imaging. 2014; 32(6): 671-678.

4. Chuang YJ^#, Zhen Z^#, Zhang F, Liu F, Mishra JP, Tang W, Chen H, Huang X, Wang L, Chen X, Xie J*, Pan Z*. Photostimulable Near-Infrared Persistent Luminescent Nanoprobes for Ultrasensitive and Longitudinal Deep-Tissue Bio-Imaging. Theranostics. 2014; 4(11): 1112-1122.

3. Zhen Z, Tang W, Guo C, Chen H, Lin X, Liu G, Fei B, Chen X, Xu B, Xie J*. Ferritin Nanocages to Encapsulate and Deliver Photosensitizers for Efficient Photodynamic Therapy against Cancer. ACS Nano. 2013; 7(8): 6988-6996.

2. Zhen Z, Tang W, Chen H, Lin X, Todd T, Wang G, Cowger T, Chen X, Xie J*. RGD-Modified Apoferritin Nanoparticles for Efficient Drug Delivery to Tumors. ACS Nano. 2013; 7(6): 4830-4837.

1. Chen H^#, Zhen Z^#, Tang W, Todd T, Chuang YJ, Wang L, Pan Z, Xie J*. Label-Free Luminescent Mesoporous Silica Nanoparticles for Imaging and Drug Delivery. Theranostics. 2013; 3(9): 650-657.